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Let's Be Clear:Find Naloxone

Anyone can be affected by substances. Having naloxone on hand can mean the difference between life and death.

To keep people in your home, office or college campus safe, have naloxone available in case of emergency. Naloxone is easy to use, widely available and could save a life. Don't wait until it's too late — find a pharmacy near you that carries naloxone.

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Let’s Be Clear:

A potential bystander was present in 43% of South Dakota overdose deaths from 2020-2024. By having naloxone on hand, lives can be saved.

Where Can I Get Naloxone in South Dakota? 

Request Naloxone

Naloxone is available for South Dakota residents to request to be shipped to their home or organization free of charge. Request a single naloxone kit for yourself or a loved one, kits to add to AED(s) for emergency use, or to distribute to individuals in your community.

Distribution Boxes

Public naloxone distribution boxes are stationed in various locations across the state where individuals can anonymously obtain a free naloxone kit. You can find a distribution box in your area using the map below.

If you currently host a large distribution box or small distribution box and need to restock, click the button below.

Small naloxone distribution box
Large Naloxone Distribution Box

Statewide Standing Order

Anyone at risk of an opioid-related overdose or those who could assist a person in an emergency situation can get naloxone or another FDA-approved opioid antagonist from a participating pharmacy through the statewide standing order. Call your pharmacy and ask if they are participating in the statewide standing order for FDA-approved opioid antagonists. For those with insurance (including Medicaid), the medication will be covered by the payor source. For those without the ability to pay (no insurance/3rd party payor source) or if you are experiencing financial circumstances that impact your ability to pay, you can get naloxone or another FDA-approved opioid antagonist for FREE at participating pharmacies.

You can also find a participating pharmacy using the map below.

On the Pharmacy Shelf as an Over-The-Counter Medication

The brand name naloxone nasal spray medication called Narcan is FDA-approved for over-the-counter use. Call or visit your local pharmacy to see if they carry Narcan for purchase.

Let's Be Clear:

Naloxone resources are available for first responders and employers through the SD Department of Health.

Naloxone Saturation and Public Access Locations

South Dakota Department of Social Services developed the Naloxone Saturation Model using suspected fatal overdoses, population data, and naloxone distribution data1. The Naloxone Saturation Model2 is a requirement by the Substance Abuse and Mental Health Services Administration (SAMHSA) aiming to ensure naloxone is sufficiently available in all sixty-six counties of South Dakota to prevent opioid-related overdose deaths. Naloxone saturation refers to the level of naloxone kit distribution at which county-level thresholds indicate sufficient coverage to support bystander access during opioid-related overdoses.

  • 1 Data Sources: Suspected fatal overdoses (HIDTA, ODMAP), population data (U.S. Census Bureau), and naloxone distribution data (SD DOH)
  • 2 Naloxone Saturation Model uses a multiple linear regression and ordinary least squares (OLS) analysis to examine the relationship between monthly naloxone distribution and overdose deaths at the county level.

To view the dashboard below on a mobile device, click here.

Find a Pharmacy 

Enter an address, city or county below to find a pharmacy participating in the statewide standing order near you. If you need more assistance finding a pharmacy, call 988.

 
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Avera Plaza 2 Pharmacy

1301 S. Cliff Ave Suite 225, Sioux Falls, SD 57105

Visit Website
605-504-0491
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Avera 69th Street Pharmacy

4400 West 69th Street Suite 300, Sioux Falls, SD 57108

Visit Website
605-322-5948
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Avera 7th Ave Pharmacy

1200 2 7th Avenue Suite 101, Sioux Falls, SD 57105

Visit Website
605-336-1816
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Avera Dermatology Pharmacy

6701 S Minnesota Avenue, Sioux Falls, SD 57108

Visit Website
605-322-6960
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Avera Grassland Pharmacy

1900 Grassland Drive Suite 101, Mitchell, SD 57301

Visit Website
605-995-5670
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Avera McKennan Campus

1325 S. Cliff Avenue Suite CP, Sioux Falls, SD 57105

Visit Website
605-322-8326
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Avera on Louise Pharmacy

6100 S. Louise Avenue Suite 1100, Sioux Falls, SD 57108

Visit Website
605-504-1351
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Avera Specialty Pharmacy

4101 West Memory Circle, Suite 135, Sioux Falls, SD 57107

Visit Website
605-322-8300
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Avera St. Mary’s Pharmacy

100 MAC Lane Suite 101, Pierre, SD 57501

Visit Website
605-224-3100
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Black Hills Pharmacy

71 Charles St, Deadwood, SD 57732

Visit Website
605-578-1512
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Boyds Drug Mart West

655 Mountain View Rd, Rapid City, SD 57702

Visit Website
605-343-4445
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Cornwell Drug

701 Main St., Webster, SD 57274

Visit Website
605-345-3351
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Costco Pharmacy #1159

3700 S Grange Ave, Sioux Falls, SD 57105

Visit Website
605-988-9150
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County Drug

1111 Lazelle Street, Sturgis, SD 57785

Visit Website
605-347-2466
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Dunes Family Pharmacy

101 Tower Road Ste 130, Dakota Dunes, SD 57049

Visit Website
605-242-5050
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Eureka Pharmacy

207 J Ave Suite 3, Eureka, SD 57437

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605-284-2752

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Family Pharmacy Clinic

1317 10th Ave W, Mobridge, SD 57601

Visit Website
605-845-8140
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Fort Thompson Indian Health Center Pharmacy

1323 BIA Route 4, Fort Thompson, SD 57339

Visit Website
605-245-1545
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Flandreau Santee Sioux Tribe Clinic Pharmacy

403 W Broad Ave, Flandreau, SD 57028

Visit Website
605-997-2642
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Genoa Healthcare (Huron)

88 3rd Street SE, STE P, Huron, SD 57350

Visit Website
605-663-1001
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Genoa Pharmacy (Rapid City)

308 Quincy Street Ste 100, Rapid City, SD 57701

Visit Website
605-646-6235
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Genoa Pharmacy (Watertown)

123 19th Street NE, Watertown, SD 57201

Visit Website
605-882-9400
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Hoffman Drug

408 Main St., Platte, SD 57369

Visit Website
605-337-3662
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Hy-Vee Pharmacy #1624

1601 S Sycamore Ave, Sioux Falls, SD 57110

Visit Website
605-334-1173
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Hy-Vee Pharmacy #1632

3000 S Minnesota Ave, Sioux Falls, SD 57105

Visit Website
605-334-8012
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Hy-Vee Pharmacy #1633

1900 S Marion Rd, Sioux Falls, SD 57106

Visit Website
 605-361-3347
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Hy-Vee Pharmacy #1637

3020 E. 10th Street, Sioux Falls, SD 57103

Visit Website
605-336-8998
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Hy-Vee Pharmacy #1820

525 W Cherry St, Vermillion, SD 57069

Visit Website
605-624-9591
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Hy-Vee Pharmacy #1871

1320 9th Ave SE, Watertown, SD 57201

Visit Website
605-886-0661
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Hy-Vee Pharmacy #1899

2100 Broadway Ave, Yankton, SD 57078

Visit Website
605-665-8261
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Hy-Vee Pharmacy #3633

304 W Highway 38 Suite 102, Hartford, SD 57033

Visit Website
605-528-2000
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James Drug

201 S. Main Ave, Wagner, SD 57380

Visit Website
605-384-3541
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Lewis Family Drug #1

2901 S Minnesota Ave, Sioux Falls, SD 57105

Visit Website
605-367-2110
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Lewis Family Drug #2

2700 W 12th St., Sioux Falls, SD 57104

Visit Website
605-367-2210
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Lewis Family Drug #3

1301 E 10th St., Sioux Falls, SD 57103

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605-367-2310
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Lewis Family Drug #4

1950 Dakota Ave. S, Huron, SD 57350

Visit Website
605-352-6496
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Lewis Family Drug #5

741 S Washington Ave, Madison, SD 57042

Visit Website
605-256-3571
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Lewis Family Drug #6

5500 W 41st St., Sioux Falls, SD 57106

Visit Website
605-367-2610
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Lewis Family Drug #7

4409 E 26th St., Sioux Falls, SD 57103

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605-367-2710
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Lewis Family Drug #9

115 N Splitrock Blvd., Brandon, SD 57005

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605-367-2910
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Lewis Family Drug #10

6109 S Louise Ave., Sioux Falls, SD 57108

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605-367-2000
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Lewis Family Drug #11

1301 E 10th St., Ste 100, Sioux Falls, SD 57103

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605-367-2831
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Lewis Family Drug #12

910 22nd Ave. S, Brookings, SD 57006

Visit Website
605-692-8881
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Lewis Family Drug #13

720 E 1st St., Tea, SD 57064

Visit Website
605-368-9001
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Lewis Family Drug #15

2525 S Ellis Road, Sioux Falls, SD 57106

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605-367-2410
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Lewis Drug #17

5830 E Madison Street, Sioux Falls, SD 57110

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605-367-2010
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Lewis Family Drug #31

109 S. Main Street, Milbank, SD 57252

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605-432-5541
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Lewis Family Drug #32

3015 3rd Ave SE, Aberdeen, SD 57401

Visit Website
605-262-0475
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Lewis Family Drug #37

204 W Main St, Elk Point, SD 57025

Visit Website
605-356-3336
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Lewis Family Drug #38

404 3rd Ave. South, Clear Lake, SD 57226

Visit Website
605-874-8220
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Lewis Family Drug #43

119 6th Ave SW, Aberdeen, SD 57401

Visit Website
605-262-0283
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Lewis Family Drug #44

925 SD HWY 10, Sisseton, SD 57262

Visit Website
605-698-2222
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Lewis Family Drug #47

135 Cliff Ave N, Harrisburg, SD 57032

Visit Website
605-213-1410
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Lewis Family Drug #48

911 11th Street SE #100, Watertown, SD 57201

Visit Website
605-878-3072
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Lewis Family Drug #50

2700 W 12th St. Suite 100, Sioux Falls, SD 57104

Visit Website
605-367-2828
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Lewis Family Drug #53

1002 N Hwy 77, Dell Rapids, SD 57022

Visit Website
605-428-5440
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Lewis Family Drug #57

211 N Commercial St, Ste A, Clark, SD 57225

Visit Website
605-532-3400
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Lewis Family Drug #58

104 W Park Ave., Viborg, SD 57070

Visit Website
605-326-5211
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Lewis Family Drug #60

715 E 5th St., Canton, SD 57013

Visit Website
605-987-4284
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Lewis Family Drug #63

515 N Pine St, Lennox, SD 57039

Visit Website
605-647-2256
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Lewis Family Drug #64

1205 S. Grange Ave. Ste 103, Sioux Falls, SD 57105

Visit Website
605-367-2620
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Lewis Family Drug #66

911 W Cedar St, Beresford, SD 57004

Visit Website
605-763-2633
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Lewis Family Drug #68

111 Calumet Ave SW, DeSmet, SD 57231

Visit Website
605-854-9033
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Lewis Family Drug #70

127 E 2nd Ave., Flandreau, SD 57028

Visit Website
605-997-2122
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Lewis Family Drug #71

1507 N Main St, Mitchell, SD 57301

Visit Website
605-292-1013
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Lewis Family Drug #78

202 E Main St, Wessington Springs, SD 57382

Visit Website
605-539-1421
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Lynn’s Dakotamart

600 National Street, Belle Fourche, SD 57717

Visit Website
605-892-2666
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Lynn’s Dakotamart

120 W. Sioux Avenue, Pierre, SD 57501

Visit Website
605-224-7396
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Lynn's Dakotamart Pharmacy: Hot Springs

509 Jensen Highway, Hot Springs, SD 57747

Visit Website
605-745-3110
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Family Pharmacy of Mobridge Clinic

1317 10th Ave W, Mobridge, SD 57601

Visit Website
605-845-8140
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Prairie Lakes Campus Pharmacy

401 9th Ave NW, Watertown, SD 57201

Visit Website
605-882-7790
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Quarve Drug

710 Main Street, Britton, SD 57430

Visit Website
605-448-2471
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Safeway #0581

2120 Mount Rushmore Road, Rapid City, SD 57701

Visit Website
605-348-7552
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Safeway #0583

1606 North Ave, Spearfish, SD 57783

Visit Website
605-642-3039
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Safeway #1554

730 Mountain View Road, Rapid City, SD 57701

Visit Website

605-342-8505

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Sam’s Club Pharmacy #6565

925 Eglin St, Rapid City, SD 57701

Visit Website
605-877-3103
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Sam's Club Pharmacy #8165

3201 S Louise Ave, Sioux Falls, SD 57106

Visit Website
605-362-2625
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Shane’s Pharmacy

213 E Hustan Ave, Ste A, Fort Pierre, SD 57532

Visit Website
605-223-9200
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The Medicine Shoppe

1304 Mount Rushmore Road, Rapid City, SD 57701

Visit Website
605-348-6305
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Walgreens #01975

1720 S Sycamore Ave, Sioux Falls, SD 57110

Visit Website
605-221-0782
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Walgreens #05242

4900 S Cliff Ave, Sioux Falls, SD 57108

Visit Website
605-357-9233
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Walgreens #05243

2605 W 12th St, Sioux Falls, SD 57104

Visit Website
605-357-9359
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Walgreens #05514

1806 S Minnesota Ave, Sioux Falls, SD 57105

Visit Website
605-221-0578
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Walgreens #05643

540 Mountain View Rd, Rapid City, SD 57702

Visit Website
605-342-6010
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Walgreens #05745

3620 W 41st St, Sioux Falls, SD 57106

Visit Website
605-361-5600
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Walgreens #09512

1125 N Lacrosse St, Rapid City, SD 57701

Visit Website
605-348-3265
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Walgreens #09806

2020 Broadway Ave, Yankton, SD 57078

Visit Website
605-665-1124
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Walgreens #10007

421 9th Ave SE, Watertown, SD 57201

Visit Website
605-882-3788
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Walgreens #10347

901 S Burr St, Mitchell, SD 57301

Visit Website
605-996-3179
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Walgreens #10572

100 E Sioux Ave, Pierre, SD 57501

Visit Website
605-224-4962
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Walgreens #10656

1902 Mount Rushmore Rd, Rapid City, SD 57701

Visit Website
605-342-0194
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Walgreens #10729

7120 W 41st St, Sioux Falls, SD 57106

Visit Website
605-221-0989
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Walgreens #12906

1430 North Ave, Spearfish, SD 57783

Visit Website
605-642-0650
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Walmart Pharmacy #1483

3001 Broadway Ave, Yankton, SD 57078

Visit Website
605-665-8197
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Walmart Pharmacy #1500

1201 29th St SE, Watertown, SD 57201

Visit Website
605-886-8419
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Walmart Pharmacy #1520

3820 7th Ave SE, Aberdeen, SD 57401

Visit Website
605-229-1519
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Walmart Pharmacy #1535

3209 S Louise Ave, Sioux Falls, SD 57106

Visit Website
605-362-1802
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Walmart Pharmacy #1538

2233 6th St, Brookings, SD 57006

Visit Website
605-692-1858
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Walmart Pharmacy #1543

2825 1st Ave, Spearfish, SD 57783

Visit Website
605-642-3025
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Walmart Pharmacy #1604

1200 N Lacrosse St, Rapid City, SD 57701

Visit Website
605-342-0881
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Walmart Pharmacy #1685

1730 N Garfield Ave, Pierre, SD 57501

Visit Website
605-224-8766
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Walmart Pharmacy #2443

7821 S Minnesota Ave, Sioux Falls, SD 57108

Visit Website
605-338-9326
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Walmart Pharmacy #2990

1101 E Spruce St, Mitchell, SD 57301

Visit Website
605-995-6845
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Walmart Pharmacy #3237

5521 E Arrowhead Pkwy, Sioux Falls, SD 57110

Visit Website
605-367-3206
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Walmart Pharmacy #3734

1207 Princeton Ave, Vermillion, SD 57609

Visit Website
605-624-4106
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Walmart Pharmacy #3853

2791 Dakota Ave S, Huron, SD 57350

Visit Website
605-353-9513
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Walmart Pharmacy #3872

100 Stumer Rd, Rapid City, SD 57701

Visit Website
605-877-3298
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Walmart Pharmacy #4865

5200 W 60th St N, Sioux Falls, SD 57107

Visit Website
605-906-6080
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Winner Pharmacy

602 W 2nd Street, Winner, SD 57580

Visit Website
605-842-7777
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Always call 911 immediately if you are experiencing a medical emergency and follow the instructions given by 911 dispatchers.

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The information on this website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. This content is presented for general reference and educational purposes to increase overall safety awareness. It is not intended to be medical or other expert advice and should not be used in place of consultation with emergency responders or medical professionals. The information published here is not exhaustive and the user should seek the advice or appropriate professionals. Official State of South Dakota Website © 2024 South Dakota Departments of Health and Social Services. All Rights Reserved.